中文名稱

纖維蛋白原

英文名字

Fibrinogen

供應商

Agrisera

產(chǎn)品貨號

IMS02-038-341

背景資料

Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).

應用類型

該纖維蛋白原產(chǎn)品的應用類型詳情查看產(chǎn)品說明書。

免疫原

Purified, full length native fibrinogen Q9UE34

來源宿主

雞

反應性

人

保存建議

Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

其他

Agrisera公司提供1000種用于植物和藻類細胞生物學研究的一抗，2000多種二抗。Agrisera公司提供的植物領域的抗體涵蓋擬南芥、萊茵衣藻、藍藻、松柏類、硅藻、大豆、大麥、蒺藜苜蓿、煙草、稻、菜豆、小立碗蘚、楊樹、豌豆、番茄、馬鈴薯、菠菜、小麥、玉米、葡萄等多個物種，此外還有水生生物類（藻類、魚）抗體，細菌、昆蟲、真菌抗體。針對植物蛋白質(zhì)的保守氨基酸序列，Agirsera還獨家開發(fā)了數(shù)十種通用抗體（global antibodies），這類抗體幾乎可以與所有的高等植物及藻類產(chǎn)生免疫反應，可為研究人員提供極為方便的選擇。