Product Name:β-Amyloid（1-40）
Synonyms:β-Amyloid（1-40）,Ultra Pure TFA
CAS No.: 131438-79-4
Catalog No.:GT-F048
Key Specification:
Appearance: White powder
Purity (HPLC) ≥95.0%
Single impurity≤1.5%
Peptide content≥70.0%
Amino Acid Composition≤±10%
Package:
Vacuum-packed with aluminum foil bag or transparent bag. 10mg,50mg, 100mg,1g,10g, 50g per package with icebag. Or according to your request.
Description:
阿爾茨海默?。?/span>AD）是一種起病隱匿的進(jìn)行性發(fā)展的神經(jīng)系統(tǒng)退行性疾病。臨床上以記憶障礙、失語、失用、失認(rèn)、視空間技能損害、執(zhí)行功能障礙以及人格和行為改變等全面性癡呆表現(xiàn)為特征。
流行病學(xué)研究表明，非甾體抗炎藥(環(huán)氧合酶抑制劑)可預(yù)防或延緩阿爾茨海默病的發(fā)病，提示腦炎癥在臨床癥狀出現(xiàn)之前就促進(jìn)了疾病進(jìn)展。
β-淀粉樣蛋白和細(xì)胞因子能促使炎性小神經(jīng)膠質(zhì)細(xì)胞激活，此過程會釋放過氧化氫、TNF-α 和 IL-1β殺傷因子。過氧化氫能促進(jìn)小神經(jīng)膠質(zhì)細(xì)胞的增殖，TNF-α（腫瘤壞死因子） 和 IL-1β（白細(xì)胞介素）是非常強(qiáng)力的生物活性因子，能迅速殺死病變的神經(jīng)元。并且被激活后的炎性小神經(jīng)膠質(zhì)細(xì)胞會長期存在于阿爾茨海默病患者的神經(jīng)炎斑塊中。
實(shí)驗(yàn)發(fā)現(xiàn)，β-淀粉樣蛋白、細(xì)胞因子和被激活的小膠質(zhì)細(xì)胞能夠強(qiáng)力的殺死共培養(yǎng)的神經(jīng)元，相比β-Amyloid（1-42），β-Amyloid（1-40）有著更好的水溶性。所以，把小神經(jīng)膠質(zhì)細(xì)胞激活并促使其殺死病變的神經(jīng)元，可能是治療此類疾病的最終手段。
Alzheimer's disease (AD) is a progressive and degenerative disease of the nervous system that begins insidiously. It is clinically characterized by comprehensive dementia manifestations such as memory impairment, aphasia, apraxia, loss of recognition, impaired visual space skills, executive dysfunction, and personality and behavior changes. Epidemiological studies have shown that non-steroidal anti-inflammatory drugs (cyclooxygenase inhibitors) can prevent or delay the onset of Alzheimer's disease, suggesting that brain inflammation promotes disease progression before clinical symptoms appear.
β-amyloid protein and cytokines can promote the activation of inflammatory microglia cells, this process will release hydrogen peroxide, TNF-α and IL-1β killing factors. Hydrogen peroxide can promote the proliferation of microglial cells. TNF-α (tumor necrosis factor) and IL-1β (interleukin) are very powerful biologically active factors that can quickly kill diseased neurons. And the activated inflammatory microglia will exist in the neuritic plaques of Alzheimer's disease patients for a long time. The experiment found that β-amyloid, cytokines and activated microglia can strongly kill co-cultured neurons. Compared with β-Amyloid (1-42), β-Amyloid (1-40) has Better water solubility. Therefore, activating microglial cells and prompting them to kill the diseased neurons may be the ultimate treatment for such diseases.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Spec.:
Sequence(3-letter code) | H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH |
Sequence(1-letter code) | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
Peptide Structure | 
|
Molecular Formula | C194H295N53O58S1 |
Molecular Weight | 4329.90 |
訂購方式：
杭州固拓生物科技有限公司
手機(jī)： +86-15572296305 （同微信號）
QQ: 3187976021
郵箱：sales4@gotopbio.com
地址：杭州下沙經(jīng)濟(jì)技術(shù)開發(fā)區(qū)銀海街600號1幢5層501 （310018）
關(guān)鍵字： β-Amyloid（1-40）;β淀粉樣肽1-40;131438-79-4;淀粉樣蛋白;多肽合成;
公司介紹
杭州固拓生物科技有限公司成立于2014年，是一家專業(yè)從事多肽以及相關(guān)衍生物研發(fā)和生產(chǎn)的國家高新技術(shù)企業(yè)，也是中國生化制藥工業(yè)協(xié)會多肽分會的理事單位。公司目前在杭州建有一個多肽研發(fā)中心，占地2000多平方米，浙江上虞和安吉有兩個商業(yè)多肽合作工廠，擁有數(shù)條完善的多肽生產(chǎn)線, 數(shù)臺大型的多肽合成設(shè)備，進(jìn)口HPLC分析和制備設(shè)備，并配有GMP標(biāo)準(zhǔn)的潔凈實(shí)驗(yàn)室。公司員工40多人，其技術(shù)骨干都是從事多肽行業(yè)15年左右，能獨(dú)立自主開發(fā)多肽項(xiàng)目。目前公司已有成熟的藥物多肽產(chǎn)品40多個，年產(chǎn)多肽可達(dá)100kg以上。定制多肽已累計達(dá)20000條，可以幫客戶提供從研發(fā)級(mg)-中試-產(chǎn)業(yè)化生產(chǎn)(kgs)的一站式服務(wù)。
我們的產(chǎn)品和服務(wù)范圍包括：
1.定制研發(fā)多肽，新抗原多肽定制合成
2.多肽原料藥中間體的生產(chǎn)
3.多肽CRO和CDMO服務(wù)
4.化妝品多肽的生產(chǎn)及配方開發(fā)
5.特殊保護(hù)氨基酸以及小分子化合物合成
6.商品化多肽庫的建立
7.新藥研究開發(fā)的技術(shù)支持