Xeruborbactam (QPX7728) 是一種有效、超廣譜的硼酸 β-內(nèi)酰胺酶 (beta-lactamase) 抑制劑。Xeruborbactam 在納米摩爾范圍內(nèi)抑制絲氨酸和金屬 β-內(nèi)酰胺酶。

In Vitro: Xeruborbactam is a potent inhibitor of Class D carbapenemases from A. baumannii.

Xeruborbactam is minimally affected by the activity of major MDR efflux pumps from P. aeruginosa, representing a significant improvement over the earlier generation boronate beta-lactamase inhibitor (BLI) vaborbactam.
The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate Xeruborbactam is a useful inhibitor for use with multiple beta-lactam antibiotics.