Product Name:Exendin-4 (3-39)
Synonyms:Exendin(3-39)
Cas No.:196109-31-6
Exendin-4 (3-39)是Exenatide的片段多肽,由37個氨基酸組成,保留了Exenatide的大部分結(jié)構(gòu)。
Exendin-4 (3-39) is a fragmented peptide of Exenatide, which consists of 37 amino acids and retains most of the structure of Exenatide.
Catalog No.:GT-P172
Key Specification:
Appearance: White powder
Purity (HPLC) ≥98.0%
Single impurity≤1.5%
Peptide content≥70.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Package:
Vacuum-packed with aluminum foil bag or transparent bag. 10mg,50mg, 100mg,1g,10g, 50g per package with icebag. Or according to your request.
Description:
艾塞那肽(exenatide)為胰高血糖素樣肽-1(GLP-1)類似物exendin-4的人工合成品,Exendin-4 (3-39)是Exenatide的片段多肽,由37個氨基酸組成,保留了Exenatide的大部分結(jié)構(gòu)。其結(jié)構(gòu)中的Asn殘基在高pH值和高溫下易發(fā)生脫酰胺反應形成Asp,His和Trp殘基較易發(fā)生氧化,由Asp參與形成的肽鍵比其他肽鍵更易水解斷裂,除Gly外,其他所有氨基酸殘基易在堿催化下發(fā)生消旋反應,在堿性條件下Thr殘基可通過β消除發(fā)生降解。因此在多肽合成過程中,需要實用合理的生產(chǎn)工藝。
Exenatide is a synthetic product of exendin-4, an analog of glucagon-like peptide-1 (GLP-1). Exendin-4 (3-39) is a fragment of Exenatide peptide, consisting of 37 amino acids , Retaining most of the structure of Exenatide. The Asn residues in its structure are prone to deamidation reaction to form Asp at high pH and high temperature. His and Trp residues are more prone to oxidation. The peptide bond formed by Asp is more prone to hydrolysis and cleavage than other peptide bonds, except for Gly , All other amino acid residues are prone to racemization reaction under base catalysis, and Thr residues can be degraded by β elimination under alkaline conditions. Therefore, in the process of peptide synthesis, a practical and reasonable production process is required.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(3-letter code) | H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
Sequence(1-letter code) | EGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
Peptide Structure | |
Molecular Formula | C176H272N46O58S |
Molecular Weight | 3992.38 |
訂購方式:
杭州固拓生物科技有限公司
手機: +86-15572296305 (同微信號)
QQ: 3187976021
郵箱:sales4@gotopbio.com
地址:杭州下沙經(jīng)濟技術(shù)開發(fā)區(qū)銀海街600號1幢5層501 (310018)
關鍵字: 196109-31-6;艾塞那肽片段多肽;Exendin-4 (3-39);多肽合成;多肽;
公司介紹
杭州固拓生物科技有限公司成立于2014年,是一家專業(yè)從事多肽以及相關衍生物研發(fā)和生產(chǎn)的國家高新技術(shù)企業(yè),也是中國生化制藥工業(yè)協(xié)會多肽分會的理事單位。公司目前在杭州建有一個多肽研發(fā)中心,占地2000多平方米,浙江上虞和安吉有兩個商業(yè)多肽合作工廠,擁有數(shù)條完善的多肽生產(chǎn)線, 數(shù)臺大型的多肽合成設備,進口HPLC分析和制備設備,并配有GMP標準的潔凈實驗室。公司員工40多人,其技術(shù)骨干都是從事多肽行業(yè)15年左右,能獨立自主開發(fā)多肽項目。目前公司已有成熟的藥物多肽產(chǎn)品40多個,年產(chǎn)多肽可達100kg以上。定制多肽已累計達20000條,可以幫客戶提供從研發(fā)級(mg)-中試-產(chǎn)業(yè)化生產(chǎn)(kgs)的一站式服務。
我們的產(chǎn)品和服務范圍包括:
1.定制研發(fā)多肽,新抗原多肽定制合成
2.多肽原料藥中間體的生產(chǎn)
3.多肽CRO和CDMO服務
4.化妝品多肽的生產(chǎn)及配方開發(fā)
5.特殊保護氨基酸以及小分子化合物合成
6.商品化多肽庫的建立
7.新藥研究開發(fā)的技術(shù)支持