Name: NCX 470
CAS#: 1194396-71-8
Chemical Formula: C31H46N2O8
Exact Mass: 574.3254
Molecular Weight: 574.715
Elemental Analysis: C, 64.79; H, 8.07; N, 4.87; O, 22.27
Description: NCX 470 is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α. It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of NCX 470 (0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.
IUPAC/Chemical Name: (S,E)-1-((1R,2R,3S,5R)-2-((Z)-7-(ethylamino)-7-oxohept-2-en-1-yl)-3,5-dihydroxycyclopentyl)-5-phenylpent-1-en-3-yl 6-(nitrooxy)hexanoate
InChi Key: NTQMJNDRYSYWNJ-BPXWCPHMSA-N
InChi Code: InChI=1S/C31H46N2O8/c1-2-32-30(36)16-10-4-3-9-15-26-27(29(35)23-28(26)34)21-20-25(19-18-24-13-7-5-8-14-24)41-31(37)17-11-6-12-22-40-33(38)39/h3,5,7-9,13-14,20-21,25-29,34-35H,2,4,6,10-12,15-19,22-23H2,1H3,(H,32,36)/b9-3-,21-20+/t25-,26+,27+,28-,29+/m0/s1
SMILES Code: O[C@@H]1C[C@@H]([C@@H]([C@H]1/C=C/[C@@H](OC(CCCCCO[N+]([O-])=O)=O)CCC2=CC=CC=C2)C/C=C\CCCC(NCC)=O)O
Appearance: Solid powder
關鍵字： 1194396-71-8;NCX 470;
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