Name: CI-898 HClCAS#: 1658520-97-8Chemical Formula: C19H26Cl3N5O3Exact Mass: 477.1101Molecular Weight: 478.8Elemental Analysis: C, 47.66; H, 5.47; Cl, 22.21; N, 14.63; O, 10.02
Description: CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
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