Name: ADL 08-0011 HCl
CAS#: 170098-43-8 (HCl)
Chemical Formula: C23H30ClNO3
Exact Mass: 403.1914
Molecular Weight: 403.947
Elemental Analysis: C, 68.39; H, 7.49; Cl, 8.78; N, 3.47; O, 11.88
Description: ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.
Synonym: ADL 08-0011 HCl; ADL 080011 HCl; ADL 08 0011 HCl; ADL08-0011 HCl; ADL-08-0011 HCl; ADL 08 0011 HCl; ADL080011 HCl;
IUPAC/Chemical Name: (S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoic acid hydrochloride
InChi Key: GHNZFXKSUXOYEJ-HWHKPKNSSA-N
InChi Code: InChI=1S/C23H29NO3.ClH/c1-17-15-24(12-11-23(17,2)20-9-6-10-21(25)14-20)16-19(22(26)27)13-18-7-4-3-5-8-18;/h3-10,14,17,19,25H,11-13,15-16H2,1-2H3,(H,26,27);1H/t17-,19-,23+;/m0./s1
SMILES Code: C[C@@]1([C@@H](C)CN(C[C@H](CC2=CC=CC=C2)C(O)=O)CC1)C3=CC(O)=CC=C3.Cl
Appearance: Solid powder
關(guān)鍵字： 170098-43-8;ADL 08-0011 HCl;
北京百奧創(chuàng)新科技有限公司是一家專注于生命科學(xué)的科技企業(yè)，由在國內(nèi)科研試劑領(lǐng)域有著豐富從業(yè)經(jīng)驗(yàn)的技術(shù)團(tuán)隊(duì)和管理團(tuán)隊(duì)組建而成，專營進(jìn)口生物試劑，科學(xué)儀器，實(shí)驗(yàn)消耗品等。公司與諸多國外品牌簽下代理，RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等，能為廣大科研用戶提供數(shù)萬種試劑、儀器和實(shí)驗(yàn)消耗品。
公司將不斷把上優(yōu)質(zhì)的產(chǎn)品引入國內(nèi)市場(chǎng)，滿足客戶的需求，公司也將緊跟生命科學(xué)的發(fā)展，為廣大科研工作者探索生命科學(xué)的奧秘奉獻(xiàn)綿薄之力！