中文名稱

2-氯-5-硝基苯甲腈； GW 9662

英文名字

2-chloro-5-nitrobenzanilide； GW 9662

供應(yīng)商

開曼生物

產(chǎn)品貨號(hào)

70785-1

產(chǎn)品報(bào)價(jià)

￥138.6/1mg

產(chǎn)品說明書

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購買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

The peroxisome proliferator-activated receptor γ （PPARγ） is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone （BRL 49653） is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists， including 15-deoxy-Δ12，14-prostaglandin J2 and azelaoyl PAF， which are naturally derived. However， only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE， which is another reported PPARγ antagonist.

產(chǎn)品描述

The peroxisome proliferator-activated receptor γ （PPARγ） is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPAR.gamma. agonists with antidiabetic actions in vivo. Rosiglitazone （BRL 49653） is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPAR.gamma. agonists， including 15-deoxy-.DELTA.12，14-prostaglandin J2 and azelaoyl PAF， which are naturally derived. However， only a few antagonists have been reported. GW 9662 blocks the PPAR.gamma.-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 uM. It is therefore a much more potent antagonist than BADGE， which is another reported PPAR.gamma. antagonist.

保存建議

建議您在收到開曼生物品牌的GW 9662 （1 mg）產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測(cè)的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務(wù).