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AZD-5069

AZD-5069 ??? ???
?? ??:
878385-84-3
???:
AZD-5069
???(??):
CS-2808;AZD-5069;CPDD1543;ACT-281959;AZD 5069; AZD5069;AZD-5069; AZD 5069; AZD5069;878385-84-3;inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors;N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide;1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-;N-(2-(((2,3-Difluorophenyl)methyl)thio)-6-(((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy)-4-pyrimidinyl)-1-azetidinesulfonamide
CBNumber:
CB52702941
???:
C18H22F2N4O5S2
??? ??:
476.52
MOL ??:
878385-84-3.mol

AZD-5069 ??

???
149-152°C
?? ?
680.5±65.0 °C(Predicted)
??
1.56±0.1 g/cm3(Predicted)
?? ??
Hygroscopic, -20°C Freezer, Under inert atmosphere
???
DMSO(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
4.56±0.20(Predicted)
??
???? ?????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 2935909099
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ?? ?? ???? ?? - ?? ?? ?? 2 ?? P260, P314, P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P314 ???? ??? ???? ??·??? ????.
P501 ...? ??? / ??? ?? ???.

AZD-5069 C??? ??, ??, ??

??

AZD5069 is a potent, selective reversible (time and temperature dependent) antagonist of the human CXCR2 receptor that used for caner treatment.

???? ??

AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.

AZD-5069 ?? ?? ? ???

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AZD-5069 ?? ??

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