125974-72-3
中文名稱
茚托利辛
英文名稱
Intoplicine
CAS
125974-72-3
分子式
C21H24N4O
分子量
348.44
MOL 文件
125974-72-3.mol
更新日期
2023/03/20 15:41:19
125974-72-3 結(jié)構(gòu)式
基本信息
中文別名
茚托利辛 英文別名
Intoplicine7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl-
11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole
物理化學(xué)性質(zhì)
熔點(diǎn)216-218 °C
沸點(diǎn)635.5±55.0 °C(Predicted)
密度1.286±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)8.26±0.30(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Intoplicine 是 DNA 拓?fù)洚悩?gòu)酶 I 和 II 抑制劑。靶點(diǎn)
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Topoisomerase I
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Topoisomerase II
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體外研究
Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex.