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Endocrinology & Hormones
PGES chemical
-
Prostaglandin Receptor agonist
Prostaglandin E2 (PGE2)
僅限科研使用
Prostaglandin E2 (PGE2)
別名: Dinoprostone 中文名稱：前列腺素E2
Prostaglandin E2 (PGE2, Dinoprostone) 在分娩中發(fā)揮重要作用（可軟化宮頸，引起子宮收縮），也刺激成骨細(xì)胞釋放能刺激破骨細(xì)胞吸收的因子。
Prostaglandin E2 (PGE2) Chemical Structure
CAS: 363-24-6
產(chǎn)品質(zhì)控
Prostaglandin E2 (PGE2)相關(guān)產(chǎn)品
| 相關(guān)化合物庫(kù) | FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 已知活性藥物庫(kù)-I 外泌體分泌相關(guān)化合物庫(kù) 人類激素相關(guān)化合物庫(kù) | 點(diǎn)擊展開 |
|---|
細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例
| 細(xì)胞系 | 實(shí)驗(yàn)類型 | 給藥濃度 | 孵育時(shí)間 | 活性描述 | 文獻(xiàn)信息 |
|---|---|---|---|---|---|
| CHO | Function assay | 100 nM | Activity at recombinant EP1 receptor (unknown origin) expressed in CHO cells co-expressing Gq protein at 100 nM by electrical cell substrate impedance sensing system | 25701254 | |
| CHO | Function assay | 100 nM | Activity at recombinant EP4 receptor (unknown origin) expressed in CHO cells co-expressing Gs protein at 100 nM by electrical cell substrate impedance sensing system | 25701254 | |
| CHO | Function assay | 100 nM | Activity at recombinant EP3 receptor (unknown origin) expressed in CHO cells co-expressing Gi protein at 100 nM by electrical cell substrate impedance sensing system | 25701254 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting, Ki = 0.0031 μM. | 22119471 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting, Ki = 0.005 μM. | 22119471 | |
| CHO | Function assay | 20 mins | Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting, Ki = 0.006 μM. | 22119471 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting, Ki = 0.022 μM. | 22119471 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.0031 μM. | 22386979 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.005 μM. | 22386979 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.006 μM. | 22386979 | |
| CHO | Function assay | 60 mins | Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting, Ki = 0.022 μM. | 22386979 | |
| CHEM1 | Function assay | 2 hrs | Displacement of [3H]PGE2 from human recombinant prostanoid EP4 receptor in CHEM1 cells after 2 hrs, Ki = 0.00045 μM. | 23403082 | |
| CHEM1 | Function assay | 2 hrs | Displacement of [3H]PGE2 from human recombinant prostanoid EP4 receptor in CHEM1 cells after 2 hrs, IC50 = 0.0011 μM. | 23403082 | |
| CHO | Function assay | 30 mins | Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method, EC50 = 0.0019 μM. | 26985320 | |
| CHO | Function assay | 30 mins | Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method, EC50 = 0.0075 μM. | 26985320 | |
| HEK293 | Function assay | 90 mins | Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay, EC50 = 0.346 μM. | 26985320 | |
| CHO | Function assay | 30 mins | Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method, EC50 = 0.347 μM. | 26985320 | |
| HEK293 | Function assay | 120 mins | Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method, IC50 = 0.00055 μM. | 27876250 | |
| HEK293 | Function assay | 120 mins | Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method, IC50 = 0.0026 μM. | 27876250 | |
| S2 | Function assay | TP_TRANSPORTER: uptake in OAT4-expressing S2 cells, Km = 0.154 μM. | 11907186 | ||
| S2 | Function assay | TP_TRANSPORTER: uptake in OCT2-expressing S2 cells, Km = 0.0289 μM. | 11907186 | ||
| HeLa | Function assay | TP_TRANSPORTER: uptake in PGT-expressing HeLa cells, K1/2 = 0.1 μM. | 8787677 | ||
| HeLa | Function assay | TP_TRANSPORTER: uptake in PGT-expressing HeLa cells, Km = 0.094 μM. | 7754369 | ||
| S2 | Function assay | TP_TRANSPORTER: uptake in OAT3-expressing S2 cells, Km = 0.345 μM. | 11907186 | ||
| S2 | Function assay | TP_TRANSPORTER: uptake in OCT1-expressing S2 cells, Km = 0.657 μM. | 11907186 | ||
| S2 | Function assay | TP_TRANSPORTER: uptake in OAT2-expressing S2 cells, Km = 0.713 μM. | 11907186 | ||
| S2 | Function assay | TP_TRANSPORTER: uptake in OAT1-expressing S2 cells, Km = 0.97 μM. | 11907186 | ||
| HEK293 | Function assay | Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells, IC50 = 0.0007 μM. | 12643927 | ||
| HEK293 | Function assay | EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor, EC50 = 0.003 μM. | 12643927 | ||
| Sf9 | Function assay | TP_TRANSPORTER: uptake (vesicle) in membrane vesicles from MRP4-expressing Sf9 cells, Km = 3.4 μM. | 12835412 | ||
| HEK293 | Function assay | Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells, Ki = 0.00033 μM. | 17531488 | ||
| HEK293 | Function assay | Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells, Ki = 0.00079 μM. | 17531488 | ||
| HEK293 | Function assay | Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells, Ki = 0.0049 μM. | 17531488 | ||
| HEK293 | Function assay | Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells, Ki = 0.0091 μM. | 17531488 | ||
| HEK293 | Function assay | Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release, EC50 = 0.0002 μM. | 19250823 | ||
| HEK293 | Function assay | Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release, EC50 = 0.0007 μM. | 19250823 | ||
| HEK293 | Function assay | Inhibition of rat EP4 receptor expressed in HEK293 cells, IC50 = 0.0021 μM. | 19250823 | ||
| HEK293 | Function assay | Inhibition of rat EP2 receptor expressed in HEK293 cells, IC50 = 0.0052 μM. | 19250823 | ||
| CHO | Function assay | Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis, EC50 = 0.0025 μM. | 26985320 | ||
| CHO | Function assay | Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis, EC50 = 0.0037 μM. | 26985320 | ||
| Chem1 | Function assay | Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis, EC50 = 0.25 μM. | 26985320 | ||
| HEK293 | Function assay | Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells, IC50 = 0.0026 μM. | 26988801 | ||
| 點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù) | |||||
生物活性
| 產(chǎn)品描述 | Prostaglandin E2 (PGE2, Dinoprostone) 在分娩中發(fā)揮重要作用（可軟化宮頸，引起子宮收縮），也刺激成骨細(xì)胞釋放能刺激破骨細(xì)胞吸收的因子。 |
|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06129604 | Recruiting | Colorectal Carcinoma (CRC)|Endometrial Carcinoma (EC) |
University of Oklahoma |
April 3 2024 | Phase 2 |
| NCT06307678 | Completed | Periapical; Infection |
Ataturk University |
July 7 2023 | Not Applicable |
| NCT06190132 | Completed | Uremic Pruritus in Hemodialysis Patients |
Ain Shams University |
April 1 2023 | Not Applicable |
化學(xué)信息&溶解度
| 分子量 | 352.47 | 分子式 | C20H32O5 |
| CAS號(hào) | 363-24-6 | SDF | Download Prostaglandin E2 (PGE2) SDF |
| Smiles | CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O | ||
| 儲(chǔ)存條件(自收到貨起) | |||
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體外溶解度 |
DMSO : 70 mg/mL ( (198.59 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO) Ethanol : 70 mg/mL (198.59 mM) Water : 2.5 mg/mL (7.09 mM) |
摩爾濃度計(jì)算器 |
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體內(nèi)溶解度 現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動(dòng)物體內(nèi)配方計(jì)算器 | ||||
實(shí)驗(yàn)計(jì)算
摩爾濃度計(jì)算器
動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）
第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）
mg/kg
g
μL
只
第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計(jì)算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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