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Tauroursodeoxycholic Acid (TUDCA)

中文名稱(chēng)：?；切苋パ跄懰?/span>

Tauroursodeoxycholic acid (TUDCA)是烏索脫氧膽酸的?；撬峁曹棶a(chǎn)物，在多種神經(jīng)退行性疾病，如阿爾茨海默病、帕金森疾病和亨廷頓疾病中，可作為線(xiàn)粒體穩(wěn)定劑和抗凋亡試劑。

Tauroursodeoxycholic Acid (TUDCA) Chemical Structure

Tauroursodeoxycholic Acid (TUDCA) Chemical Structure

CAS: 14605-22-2

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買(mǎi)數(shù)量
10mM (1mL in DMSO) 1203.93 現(xiàn)貨
25mg 1040.45 現(xiàn)貨
1g 7944.3 現(xiàn)貨
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Tauroursodeoxycholic Acid (TUDCA)相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類(lèi)型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
HuH7 Cytoprotective assay 1 mM 24 hrs Cytoprotective activity against DCA-induced cell death in human HuH7 cells assessed as increase in cell viability at 1 mM preincubated with cells followed by DCA addition measured after 24 hrs by MTT/INCELL assay 27729186
HEK293 Function assay 90 mins Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay, IC50=10.3μM 28165241
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of CHOP mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against DCA-induced ER stress in human HuH7 cells assessed as increase in XBPu mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as increase in XBPu mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against DCA-induced ER stress in human HuH7 cells assessed as inhibition of XBPs mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of XBPs mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as reduction in XBPs/XBPu ratio after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of BIP/GRP78 mRNA levels after 6 hrs 27729186
CHO cells Function assay Agonist activity at human TGR5 expressed in CHO cells by luciferase assay, EC50=30 μM 18307294
Sf9 Function assay TP_TRANSPORTER: uptake in membrane vesicles from Bsep-expressing Sf9 cells, Km=4.1μM 10648470
MDCK Function assay TP_TRANSPORTER: uptake in Oatp3-expressing MDCK cells, Km=6.6μM 11093941
Sf9 Function assay TP_TRANSPORTER: uptake in membrane vesicles isolated from Bsep-expressing Sf9 cells, Km=11.9μM 12404240
CHO Function assay TP_TRANSPORTER: uptake in Ntcp-expressing CHO cells, Km=14μM 9486191
COS Function assay TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells, Ki=28μM 9458785
HEK293 Function assay Non-competitive inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in LPC hydrolysis by Lineweaver-Burk plot analysis 28165241
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述 Tauroursodeoxycholic acid (TUDCA)是烏索脫氧膽酸的?；撬峁曹棶a(chǎn)物，在多種神經(jīng)退行性疾病，如阿爾茨海默病、帕金森疾病和亨廷頓疾病中，可作為線(xiàn)粒體穩(wěn)定劑和抗凋亡試劑。
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05753852 Recruiting
Amyotrophic Lateral Sclerosis
Humanitas Mirasole SpA|University of Ulm|University of Sheffield|University Hospital Tours|KU Leuven|UMC Utrecht|University of Dublin Trinity College|Bruschettini S.r.l.|Istituto Superiore di Sanità|Motor Neurone Disease Association
 October 25 2021 Phase 3
NCT04114292 Unknown status
Ulcerative Colitis
Washington University School of Medicine|Crohn''s and Colitis Foundation
 January 17 2019 Phase 1
NCT01899703 Completed
Cholestasis Intrahepatic
GlaxoSmithKline
 March 10 2014 Phase 2

化學(xué)信息&溶解度

分子量 499.70 分子式

C26H45NO6S
CAS號(hào) 14605-22-2 SDF Download Tauroursodeoxycholic Acid (TUDCA) SDF
Smiles CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 100 mg/mL ( (200.12 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開(kāi)封DMSO)

Water : 100 mg/mL (200.12 mM)

Ethanol : 50 mg/mL (100.06 mM)

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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