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  2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Obidoxime dichloride

Obidoxime dichloride 是一種非全譜肟試劑，可作為有機(jī)磷類神經(jīng)毒劑中毒的解毒劑。Obidoxime dichloride 可活化被沙林蛋白抑制的乙酰膽堿酯酶 (AChE)，降低沙林蛋白的急性毒性。

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Obidoxime dichloride Chemical Structure

Obidoxime dichloride Chemical Structure

CAS No. : 114-90-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥936
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查看 Cholinesterase (ChE) 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1].

體內(nèi)研究
(In Vivo)

Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD50 of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI male mice
Dosage: 10 mg/kg
Administration: Intramuscular injection
Result: Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE).
分子量

359.21

Formula

C14H16Cl2N4O3
CAS 號(hào)
性狀

固體

顏色

Off-white to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

純度 & 產(chǎn)品資料

純度: 96.60%

參考文獻(xiàn)

Obidoxime dichloride 相關(guān)分類

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Obidoxime dichloride
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