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  2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. SUN 1334H

SUN 1334H 是一種有效的，可口服的，選擇性的 H1 receptor 拮抗劑，Ki 值為 9.7 nM。

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SUN 1334H Chemical Structure

SUN 1334H Chemical Structure

CAS No. : 607736-84-5

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規(guī)格 價(jià)格 是否有貨
1 mg ￥1000
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Other Forms of SUN 1334H:

查看 Histamine Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM.

IC50 & Target

H1 Receptor

 

體外研究
(In Vitro)

SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K+-currents at concentrations as high as 100 μM[1]. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs[1]. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

489.38

Formula

C23H28Cl2F2N2O3
CAS 號
性狀

固體

顏色

Light yellow to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
SUN 1334H
目錄號：
HY-U00084
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