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  4. Tiopinac

Tiopinac  (Synonyms: 硫平酸; RS 40974)

目錄號(hào): HY-U00063 純度: ≥99.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Tiopinac (RS 40974) 是一種二苯并噻吩，是具有口服活性且高度有效的抗炎和解熱劑。

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Tiopinac Chemical Structure

Tiopinac Chemical Structure

CAS No. : 61220-69-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2550
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  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Tiopinac (RS 40974), a dibenzthiepin, is an orally active and highly potent anti-inflammatory and anti-pyretic agent[1].

體內(nèi)研究
(In Vivo)

Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

284.33

Formula

C16H12O3S
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

硫平酸
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

Female rats, 160-180 g, receive 0.1 mL of a suspension in mineral oil of heatkilled M. butyricum (10 mg/mL) by means of two intradermal injections (0.05 mL each) into the proximal 1/4 of the tail on day 0. When the test agent is studied for its activity versus the development of the arthritic syndrome, it is administered p.o. (0.5 mL vehicle/dose) twice each day (at 9 a.m. and 4 p.m.) for 17 days, beginning on day 1. On day 18 the intensity of the swelling of the four foot pads and tail is determined blindly utilizing a scoring system in which the swelling in the four paws is scored 0-4 for each paw and the tail swelling is scored 0-3. The total maximum score is 19. The body weights and the weights of both hind paws are obtained. This procedure is a modification of a system initially described by PEARSON.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

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產(chǎn)品名稱：
Tiopinac
目錄號(hào)：
HY-U00063
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