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  2. Immunology/Inflammation Apoptosis
  3. Interleukin Related Apoptosis
  4. Benralizumab

Benralizumab  (Synonyms: 貝那利珠單抗; MEDI-563; BIW-8405)

目錄號: HY-P9923 純度: 99.1%
COA

Benralizumab (MEDI-563) 是一種白介素 5 受體 α (IL-5Rα) 定向的溶細(xì)胞單克隆抗體，通過增強抗體依賴性細(xì)胞介導(dǎo)的細(xì)胞毒性誘導(dǎo)嗜酸性粒細(xì)胞直接，快速和幾乎完全耗盡。Benralizumab 可用于嚴(yán)重的嗜酸性哮喘。

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CAS No. : 1044511-01-4

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規(guī)格 價格 是否有貨
1 mg ￥4800
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Benralizumab 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Benralizumab:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma[1].

同型

Human IgG1 kappa
推薦同型對照抗體
種屬

Humanized
IC50 & Target[1]

IL-5Rα

 

體外研究
(In Vitro)

Benralizumab (MEDI-563) binds to recombinant human and cynomolgus monkey IL-5Rα extracellular domains with a dissociation constant of 11 and 42 pM, respectively[2].
Benralizumab (1 pM-100 nM, 48 h) inhibits IL-5–induced proliferation of CTLL-2 cells transfected with recombinant human IL-5Rαβ with an IC50 of 0.3 nM[2].
Benralizumab binds only to the constructs containing human IL-5Rα D1[2].
Benralizumab mediates ADCC (antibody-dependent cell-mediated cytotoxicity) of human eosinophils and basophils with EC50s of 0.9 pM and 0.5 pM, respectively, and mediates eosinophil apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: CTLL-2 human IL-5Rαβ cells
Concentration: 1 pM-100 nM
Incubation Time: 48 h
Result: Inhibited cell proliferation with an IC50 of 0.3 nM.
體內(nèi)研究
(In Vivo)

Benralizumab (MEDI-563) (0-30 mg/kg; i.v.; once every 3 weeks for 12 weeks) reduces peripheral blood and bone marrow eosinophil[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male cynomolgus monkeys[2]
Dosage: 0.1, 1, 10, and 30 mg/kg
Administration: Intravenous injection, once every 3 weeks for 12 weeks
Result: Blood eosinophil counts decreased close to the limit of detection after the first administration at all dose levels and remained undetectable. Eosinophil precursors in the bone marrow were reduced 80% or greater in all doses 3 days after the last administration (terminal necropsy) and remained undetectable until 18 days after the last dose in the 30 mg/kg group. The profound effect observed in the bone marrow was specific for the eosinophil lineage.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

貝那利珠單抗
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料

純度: ≥99.1%

參考文獻(xiàn)

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Benralizumab
目錄號：
HY-P9923
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