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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Ustekinumab

Ustekinumab  (Synonyms: 烏司奴單抗; Anti-Human IL-12/IL-23, Human Antibody)

目錄號: HY-P9909 純度: 98.42%
COA

Ustekinumab 是一種抗 IL-12/IL-23 的人源單克隆 IgG1κ 抗體。

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CAS No. : 815610-63-0

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥4500
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MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 實驗參考方法

  • 純度 & 產品資料

  • 參考文獻

生物活性

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

同型

Human IgG1 kappa
推薦同型對照抗體
種屬

Human
IC50 & Target

IL-12

 

IL-23

 

體外研究
(In Vitro)

Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells[1]. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

145625.97

CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

尤特克單抗； 烏司奴單抗； 優(yōu)特克單抗
運輸條件

Shipping with dry ice.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized IL-12?beta Protein, Human (HEK293, Fc, HY-P73160) can bind Ustekinumab. The EC50 for this effect is 13.6 ng/mL.
純度 & 產品資料

純度: 98.42%

參考文獻
Cell Assay
[2]

HUVECs are grown on calibrated glass coverslips to a confluency of 80%. Subsequently, cells are incubated with 200 μg/mL Ustekinumab AlexaFluor488 and Briakinumab AlexaFluor594 for 20 min at 37°C, pH 7.3, washed three times, and chased in fresh medium for an additional 20 min before fixation. Antibodies are directly labeled. FcRn binding is quality controlled by SPR analysis. Cells are then counterstained with anti-FcRn monoclonal antibody DVN22, followed by anti-mouse secondary antibodies conjugated to AlexaFluor647. Imaging is performed on a Leica SP8 confocal microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Ustekinumab
目錄號：
HY-P9909
需求量：