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  2. GPCR/G Protein
  3. CRFR
  4. Urocortin, rat

Urocortin, rat  (Synonyms: Urocortin (Rattus norvegicus); Rat urocortin)

目錄號(hào): HY-P1296 純度: 96.58%
COA 產(chǎn)品使用指南

Urocortin, rat (Urocortin (Rattus norvegicus)) 是一種神經(jīng)肽，也是一種有效的內(nèi)源性 CRFR 激動(dòng)劑，對(duì)人 CRF1，大鼠 CRF2α 和小鼠 CRF2β 的 Ki 分別為 13 nM，1.5 nM 和 0.97 nM。

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Custom Peptide Synthesis

Urocortin, rat Chemical Structure

Urocortin, rat Chemical Structure

CAS No. : 171543-83-2

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1 mg ￥1800
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5 mg ￥4200
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Other Forms of Urocortin, rat:

查看 CRFR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively[1][2].

IC50 & Target

CRFR1

 

CRFR2

 

體外研究
(In Vitro)

Urocortin, rat induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively in stably transfected Chinese hamster ovary cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4707.26

Formula

C206H338N62O64
CAS 號(hào)
性狀

固體

顏色

White to off-white

Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Sequence Shortening

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : < 0.1 mg/mL (adjust pH to 5 with 0.01 M Acetic acid) (insoluble)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Urocortin, rat
目錄號(hào)：
HY-P1296
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