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  2. Anti-infection
  3. Bacterial
  4. LL-37, human acetate

LL-37, human acetate 

目錄號: HY-P1222B 純度: 99.50%
COA 產(chǎn)品使用指南

LL-37, human acetate 是一種具有 37 個殘基的兩親性組織蛋白酶衍生的抗菌肽，具有廣泛的抗菌活性。LL-37, human acetate 有助于保護角膜免受感染，調(diào)節(jié)傷口愈合。

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Custom Peptide Synthesis

LL-37, human acetate Chemical Structure

LL-37, human acetate Chemical Structure

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1250
In-stock
5 mg ￥2600
In-stock
10 mg ￥4030
In-stock
50 mg   詢價  
100 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of LL-37, human acetate:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing[1][2][3].

體外研究
(In Vitro)

LL-37，human acetate (1 -20 μg/mL；24 h) 影響 HCECs 遷移[2]。
LL-37，human acetate (0.0001-5 μg/mL；6-24 h) 影響 HCECs 中的細(xì)胞因子分泌[2]。
LL-37，human acetate (1-100 μg/mL；24 h) 在一定濃度下對 HCECs 表現(xiàn)出劑量依賴性細(xì)胞毒性超過 10 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [2]

Cell Line: Human corneal epithelial cell (HCEC)
Concentration: 1, 2.5, 5, 10 and 20 μg/mL
Incubation Time: 24 hours
Result: Dose-dependently stimulated HCEC migration but showed no effect on cells proliferation.

Cell Viability Assay[2]

Cell Line: Human corneal epithelial cell (HCEC)
Concentration: 0.0001, 0.001, 0.01, 0.1, 0.5, 1, and 5 μg/mL
Incubation Time: 6 and 24 hours
Result: Dose-dependently increased IL-8, IL-6, IL-1β and TNF-α secretion at 6 and 24 hours in HCEC.
體內(nèi)研究
(In Vivo)

LL-37，human acetate (0.4-2.0 mg/kg；氣管內(nèi)注射一次) 改善 MRSA 誘導(dǎo)的小鼠肺炎[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week-old C57BL/6 mice with MRSA-induced pneumonia[3]
Dosage: 0.4, 0.8, 1.2, 1.6 and 2.0 mg/kg
Administration: Intratracheal injection; 0.4-2.0 mg/kg once
Result: Decreased IL-6 and TNF-α release to attenuated MRSA-induced pneumonia of testing mice.
分子量

4493.26 (free base)

Formula

C205H340N60O53.xC2H4O2
性狀

固體

顏色

White to off-white

Sequence Shortening

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : 100 mg/mL (超聲助溶)

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
LL-37, human acetate
目錄號：
HY-P1222B
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