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  2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Angoline hydrochloride

Angoline hydrochloride 是一種有效的、選擇性的 IL6/STAT3 信號(hào)通路抑制劑，IC50 為 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表達(dá)，并抑制癌細(xì)胞增殖。

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Angoline hydrochloride Chemical Structure

Angoline hydrochloride Chemical Structure

CAS No. : 1071676-04-4

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Angoline hydrochloride 的其他形式現(xiàn)貨產(chǎn)品:

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Other Forms of Angoline hydrochloride:

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

IC50 & Target

IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)[1]
體外研究
(In Vitro)

Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively[1].
Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3[1].
Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HepG2/STAT3 cell lines
Concentration: 0, 1, 10, 30 and 100 μM
Incubation Time: 2 hours
Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.

Western Blot Analysis[1]

Cell Line: MDA-MB-231, H4 and HepG2 cell lines
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.
分子量

415.87

Formula

C22H22ClNO5
CAS 號(hào)
結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Angoline hydrochloride
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HY-N7674A
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