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  2. Anti-infection Apoptosis
  3. Bacterial Parasite Apoptosis
  4. Aflatoxin M1

Aflatoxin M1  (Synonyms: 黃曲霉毒素 M1)

目錄號: HY-N6699 純度: 99.43%
COA 產(chǎn)品使用指南

Aflatoxin M1 是 Aflatoxin B1 的主要代謝產(chǎn)物。Aflatoxin M1 是一種具有口服活性的由 Aspergillus flavus 和 Aspergillus parasiticus 產(chǎn)生的一種霉菌毒素。毒性順序為 Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2。

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Aflatoxin M1 Chemical Structure

Aflatoxin M1 Chemical Structure

CAS No. : 6795-23-9

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規(guī)格 價格 是否有貨 數(shù)量
100 μg ￥3200
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Other Forms of Aflatoxin M1:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is an orally active mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2[1][2][3].

體外研究
(In Vitro)

Aflatoxin M1 (0.5, 1 μg/mL, 24-72 h) 可呈時間和劑量依賴性的抑制 Caco-2 細(xì)胞的生長[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Caco-2
Concentration: 0.01, 0.05, 0.1, 0.5, 1 μg/mL
Incubation Time: 24, 48, 72 h
Result: Inhibited cell viability at concentrations 0.5 and 1 μg/mL.
體內(nèi)研究
(In Vivo)

Aflatoxin M1 (3.5 g/kg, 灌胃, 每天一次連續(xù) 28 天) 通過改變 PRODH 和 L-脯氨酸的表達(dá)激活氧化應(yīng)激，進(jìn)而誘導(dǎo) CD-1 小鼠下游細(xì)胞凋亡，從而引起腎毒性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice model[3]
Dosage: 3.5 g/kg
Administration: i.g. once a day for 28 days
Result: Elevated MDA level and decreased SOD, T-AOC.
分子量

328.27

Formula

C17H12O7
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

黃曲霉毒素 M1
結(jié)構(gòu)分類
初始來源

Aspergillus flavus and Aspergillus parasiticus
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料

純度: 99.43%

參考文獻(xiàn)

  • 摩爾計算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aflatoxin M1
目錄號：
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