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  2. Metabolic Enzyme/Protease Anti-infection Apoptosis Autophagy
  3. Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy
  4. Calcimycin hemimagnesium

Calcimycin hemimagnesium  (Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

目錄號: HY-N6687B
產(chǎn)品使用指南

Calcimycin (A-23187) hemimagnesium 是一種抗生素和獨特的二價陽離子離子載體 (divalent cation ionophore)，如鈣離子和鎂離子。Calcimycin hemimagnesium 通過增加細胞內(nèi)鈣濃度誘導(dǎo) Ca2+ 依賴性細胞死亡。Calcimycin hemimagnesium 抑制革蘭氏陽性細菌和一些真菌的生長，還抑制 ATP 酶的活性并解耦哺乳動物細胞的氧化磷酸化 (OXPHOS)，誘導(dǎo)細胞凋亡 (apoptosis)。

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Calcimycin hemimagnesium Chemical Structure

Calcimycin hemimagnesium Chemical Structure

CAS No. : 72124-77-7

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Calcimycin hemimagnesium 的其他形式現(xiàn)貨產(chǎn)品:

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].

體外研究
(In Vitro)

Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (ICR, 25-30 g)[5]
Dosage: 2.5 or 7.5 nM
Administration: Intrapleurally
Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
Clinical Trial
分子量

1069.53

Formula

C58H72MgN6O12
CAS 號
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Calcimycin hemimagnesium
目錄號：
HY-N6687B
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