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  2. Anti-infection TGF-beta/Smad Stem Cell/Wnt
  3. Parasite PKA
  4. Warangalone

Warangalone  (Synonyms: 攀登魚藤異黃酮; Scandenolone)

目錄號: HY-N1074
COA 產(chǎn)品使用指南 技術(shù)支持

Warangalone 是抗瘧疾化合物，能夠抑制 3D7 (氯喹敏感) 和 K1 (氯喹耐藥) 寄生蟲的生長， IC50 值分別為 4.8 μg/mL 和 3.7 μg/mL。 Warangalone 還可以抑制環(huán) AMP 依賴性蛋白激酶催化亞基 (cAK)，其 IC50 值為 3.5 μM。

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Warangalone Chemical Structure

Warangalone Chemical Structure

CAS No. : 4449-55-2

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規(guī)格 價格 是否有貨
1 mg ￥3341
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  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50 of 3.5 μM.

IC50 & Target

Plasmodium

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
8.5 μM
Compound: 18
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 31403786]
體外研究
(In Vitro)

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively[1]. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50 of 3.5 μM[2]. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

404.46

Formula

C25H24O5
CAS 號
性狀

固體

顏色

Light yellow to yellow

中文名稱

攀登魚藤異黃酮
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Kinase Assay
[3]

The enzyme activities of caspase-3 and caspase-9 are measured using a caspase fluorometric assay kit. Cells are seeded in 24-well plates at a density of 3×106 cells per well. After exposure of the cells to Warangalone for the allotted time periods, the cells are washed three times with PBS, and then lysed in a lysis buffer for 10 min on ice. The protein content of the cell lysates is assayed with a Micro BCA reagent. Cell lysates containing 50 μg of protein are incubated with a caspase-3 fluorogenic substrate (DEVD-AFC) or a caspase-9 fluorogenic substrate (LEHD-AFC) for 1 h at 37°C. Caspase activity is measured by fluorometric detection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay
[3]

Cell viability is determined using the Cell Titer 96 Aqueous assay kit. Cells are seeded in 96-well plates at a density of 1×105 cells per well. The cells are maintained for 24 h at 37°C and then Warangalone (30 μM) is added to the culture medium. MTS solution is added to the 96-well plates at the indicated time points, and the cells are incubated for 1 h at 37°C. The absorbance is measured at a wavelength of 490 nm with a microplate counter[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Warangalone
目錄號：
HY-N1074
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