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  1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. CP-465022 hydrochloride

CP-465022 hydrochloride 是一種強(qiáng)效的、選擇性的、非競(jìng)爭(zhēng)性的 AMPA受體 拮抗劑,具有抗驚厥活性。CP-465022 對(duì) Kainate 誘導(dǎo)反應(yīng)具有抑制作用,IC50 為 25 nM。CP-465022 是研究 AMPA 受體在生理和病理方面研究的有效工具。

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CP-465022 hydrochloride Chemical Structure

CP-465022 hydrochloride Chemical Structure

CAS No. : 1785666-59-2

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CP-465022 hydrochloride 的其他形式現(xiàn)貨產(chǎn)品:

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生物活性

CP-465022 hydrochloride is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50?of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes[1][2].

IC50 & Target

IC50: 25 nM (rat cortical neurons)[1]

體外研究
(In Vitro)

CP-465022 (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC50 of 25 nM and essentially complete inhibition at 3.2 μM[1].
CP-465022 1 μM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 μM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons[1].
CP-465022 1 μM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons[1].
CP-465022 (100 nM -10 μM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 μM CP-465,022 nearly complete inhibits this time frame (99.3%)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

499.41

Formula

C26H25Cl2FN4O

CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

純度 & 產(chǎn)品資料
參考文獻(xiàn)
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產(chǎn)品名稱:
CP-465022 hydrochloride
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HY-18663B
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