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  4. Emiglitate

Emiglitate  (Synonyms: BAY o 1248)

目錄號: HY-16194 純度: ≥98.0%
COA 產(chǎn)品使用指南

Emiglitate (BAY o 1248)是有效的，競爭選擇性的α-glucoside hydrolase抑制劑。

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Emiglitate Chemical Structure

Emiglitate Chemical Structure

CAS No. : 80879-63-6

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥5072
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  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.

體外研究
(In Vitro)

Emiglitate greatly suppresses the glucose-stimulated insulin release in parallel with an inhibitory effect on the activities of acid glucan-1,4-α-glucosidase and acid α-glucosidase. In contrast, the activities of acid phosphatase and N-acetyl-β-D-glucosaminidase tend to increase in the presence of the α-glucoside hydrolase inhibitor. The CO-induced amplification of the glucose-stimulated insulin release as well as of the increased activities of the acid α-glucoside hydrolases are abrogated by emiglitate and displayed the same levels as in the absence of CO. The CO-induced rise in the activities of acid phosphatase and acid N-acetyl-β-D-glucosaminidase is not appreciably affected by emiglitate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

In fasted rats, emiglitate inducec a significant, dose-dependent increase of hepatic glycogen concentrations. The increase in hepatic glycogen is due to lysosomal storage of glycogen only. Emiglitate in the amount of 5 mg/kg b.wt. does not induce significant changes either of glycogen concentrations or at the EM-level[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

355.38

Formula

C17H25NO7
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻
Kinase Assay
[1]

Effect of the selective α-glucoside hydrolase inhibitor emiglitate (100 μM) on glucose-stimulated insulin secretion and islet lysosomal enzyme activities at 12 mM glucose in the absence and presence of CO gas is studied. Islets are incubated in the absence (open columns) or presence (solid columns) of emiglitate. Experiments are performed both in the presence (the two columns to the right) and in the absence (the two columns to the left) of exogenous CO[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

Emiglitate 相關分類

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Emiglitate
目錄號：
HY-16194
需求量：