天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

  2. Neuronal Signaling
  3. Serotonin Transporter
  4. Desvenlafaxine succinate

Desvenlafaxine succinate  (Synonyms: O-Desmethylvenlafaxine succinate; Wy-45233 succinate)

目錄號: HY-16170
產(chǎn)品使用指南

Desvenlafaxine succinate 是 Venlafaxine (HY-B0196) 主要代謝物的丁二酸鹽形式，是具有口服活性的、能透過血腦屏障的 5-HT 和 去甲腎上腺素 (norepinephrine) 再攝取的抑制劑，對hSERT和hNET 的IC50值分別為47.3 nM和531.3 nM。Desvenlafaxine succinate (DVS) 在人多巴胺(DA)轉(zhuǎn)運體上顯示弱的結(jié)合親和力。

該產(chǎn)品由公安部研究所生產(chǎn)，銷售、運輸全流程受嚴(yán)格監(jiān)管。MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，請您遵守承諾用途，不得違反法律法規(guī)規(guī)定用于任何其他用途。

Desvenlafaxine succinate Chemical Structure

Desvenlafaxine succinate Chemical Structure

CAS No. : 448904-47-0

1.  客戶無需承擔(dān)相應(yīng)的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 是否有貨
50 mg   詢價  
100 mg   詢價  
250 mg   詢價  

* Please select Quantity before adding items.

Desvenlafaxine succinate 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Desvenlafaxine succinate:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Desvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

IC50 & Target

IC50: 47.3 nM (hSERT), 531.3 nM (hNET)[1].
體外研究
(In Vitro)

Desvenlafaxine succinate has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Desvenlafaxine succinate also induces CYP3A4, which could impact the metabolism of drugs metabolized via this enzyme[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Desvenlafaxine succinate (30 mg/kg, orally) significantly increases extracellular NE levels but had no effect on DA levels using microdialysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats[1].
Dosage: 30 mg/kg.
Administration: Orally.
Result: Significantly increased extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis.
分子量

381.46

Formula

C20H31NO6
CAS 號
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機構(gòu)名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
Desvenlafaxine succinate
目錄號：
HY-16170
需求量：