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  2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Synucleozid

Synucleozid (NSC 377363) 是可編碼 α-突觸核蛋白的 SNCA?mRNA 的有效抑制劑。Synucleozid 選擇性靶向 α-synuclein mRNA 的 5'UTR 設(shè)計(jì) IRE 位點(diǎn)，減少了加載到多核糖體中的 SNCA mRNA 的量，從而抑制了α-synuclein 蛋白的翻譯。Synucleozid 有潛力用于帕金森病的相關(guān)研究。

該游離形式化合物不穩(wěn)定，推薦具有相同生物學(xué)活性的穩(wěn)定鹽形式 Synucleozid hydrochloride。

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Synucleozid Chemical Structure

Synucleozid Chemical Structure

CAS No. : 502139-01-7

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Synucleozid 的其他形式現(xiàn)貨產(chǎn)品:

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Other Forms of Synucleozid:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Synucleozid (NSC 377363) is a potent inhibitor of the SNCA?mRNA that encodes α-synuclein protein. Synucleozid selectively?targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of?SNCA mRNA loaded into polysomes and thereby inhibits?SNCA?translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
CMK IC50
1.31 μM
Compound: K313
Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
HEL IC50
2.27 μM
Compound: K313
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
K562 IC50
1.08 μM
Compound: K313
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
MEG-01 IC50
1.03 μM
Compound: K313
Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
體外研究
(In Vitro)

Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate[1].
Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells[1].
Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50?value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled?SNCA?IRE RNA (RNA-0) concentration, affording a competitive?Kd?of 1.5 ± 0.3 μM[1].
Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 0.25 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Decreased LDH release as a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 0.25 μM; 0.5 μM; 1 μM;
Incubation Time: 24 hours
Result: Decreased α-synuclein expression as a concentration-dependent manner.
分子量

368.43

Formula

C22H20N6
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Synucleozid
目錄號(hào)：
HY-135902
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