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  2. Anti-infection
  3. Dengue virus Flavivirus Antibiotic
  4. Hymeglusin

Hymeglusin  (Synonyms: F-244; 1233A; L-659699)

目錄號: HY-117430 純度: ≥98.0%
COA 產(chǎn)品使用指南

Hymeglusin 作為一種真菌 β-內(nèi)酯 antibiotic，是一種 HMG-CoA 合酶抑制劑 (IC50 = 0.12 μM)。 Hymeglusin 共價修飾酶的活性 Cys129 殘基。

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Hymeglusin Chemical Structure

Hymeglusin Chemical Structure

CAS No. : 29066-42-0

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規(guī)格 價格 是否有貨 數(shù)量
500 μg ￥5100
In-stock
1 mg 現(xiàn)貨 詢價
5 mg   詢價  
10 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].

IC50 & Target

IC50: 1.2 μM (HMG-CoA)[2][3]
體外研究
(In Vitro)

Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC50/IC50) of Hymeglusin is 11. The EC50 of Hymeglusin in K562 cells is 4.5 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.41

Formula

C18H28O5
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
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產(chǎn)品名稱：
Hymeglusin
目錄號：
HY-117430
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