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  1. Metabolic Enzyme/Protease
  2. Drug Metabolite Endogenous Metabolite
  3. Leukotriene D4

Leukotriene D4 是一種有效的支氣管收縮劑。Leukotriene D4 具有研究哮喘的潛力。Leukotriene D4 誘導(dǎo)水腫并增加毛細(xì)血管通透性。

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Leukotriene D4 Chemical Structure

Leukotriene D4 Chemical Structure

CAS No. : 73836-78-9

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10 μg (201.34 μM * 100 μL in Ethanol) ¥1800
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50 μg (201.34 μM * 500 μL in Ethanol) 現(xiàn)貨 詢價(jià)

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Customer Review

Other Forms of Leukotriene D4:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability[1][2].

IC50 & Target

Human Endogenous Metabolite

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
0.7 nM
Compound: LTD4
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
[PMID: 23403082]
體內(nèi)研究
(In Vivo)

Leukotriene D4 (1.5, 3, 6, 12, 24 μg/paw; injected intradermally) causes edema and increases capillary permeability in a dose-related manner in mouse[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 21-24 g, Balb/c male mice[2]
Dosage: 1.5, 3, 6, 12, 24 μg/paw
Administration: Injected intradermally (10 μL was injected into the left hind paw)
Result: Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.
Clinical Trial
分子量

496.66

Formula

C25H40N2O6S

CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Solution, -20°C, 2 years

純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)
  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Leukotriene D4
目錄號(hào):
HY-113456
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