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  2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Chlorcyclizine

Chlorcyclizine  (Synonyms: 氯環(huán)利嗪；氯環(huán)力嗪)

目錄號: HY-112067
產(chǎn)品使用指南

Chlorcyclizine 是一種組胺 H1 拮抗劑。

該產(chǎn)品由公安部研究所生產(chǎn)，銷售、運(yùn)輸全流程受嚴(yán)格監(jiān)管。MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，請您遵守承諾用途，不得違反法律法規(guī)規(guī)定用于任何其他用途。

Chlorcyclizine Chemical Structure

Chlorcyclizine Chemical Structure

CAS No. : 82-93-9

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100 mg   詢價(jià)  
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Chlorcyclizine 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Chlorcyclizine:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 Histamine Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Chlorcyclizine is a histamine H1 antagonist.

IC50 & Target

Histamine H1[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 CC50
49.8 μM
Compound: Rac-2
Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis
Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis
[PMID: 26599718]
Huh-7.5 CC50
30.22 μM
Compound: CCZ
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35050619]
Huh-7.5 CC50
30.79 μM
Compound: CCZ
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35050619]
體內(nèi)研究
(In Vivo)

Pregnant rats administered 30, 60, and 90mg/kg Chlorcyclizine during the sensitive period for palate development survived until scheduled sacrifice on Gestation Days (GDs) 17 or 21. The rats administered 60 or 90mg/kg Chlorcyclizine have transient adverse clinical signs (chromorhinorrhea, red peri-oral substance, urogenital staining, and scant stool) and a concomitant body weight loss of 7% and 11%, respectively, over the dosing interval. Rats administered 30mg/kg Chlorcyclizine do not exhibit any adverse clinical signs, but do not gain weight over the dose interval as would be expected during pregnancy. Based on the testing facility’s historical control database (16 studies, n=380). pregnant rats typically gain about 6% body weight from GDs 12 to 15[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

300.83

Formula

C18H21ClN2
CAS 號
中文名稱

氯環(huán)利嗪；氯環(huán)力嗪
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

Rats[1]
Timed-mated CRL:CD [SD] female rats between 9 and 13 weeks of age at initiation of dosing and weighing between 245 and 363 g are used. Rats are administered a single daily oral gavage dose of 30, 60, or 90 mg/kg Chlorcyclizine (n=8/group) during the sensitive period for palate development, GDs 11 to 14. These doses are selected such that 30 mg/kg is a likely no-effect dose and higher doses of 60 and/or 90 mg/kg will induce a moderate or high incidence of fetal cleft palate. Given that CRL:CDs [SD] rats have an extremely low incidence of spontaneous cleft palate in the testing laboratory, as well as to avoid unnecessary use of animals, a methylcellulose control group is omitted[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Chlorcyclizine
目錄號：
HY-112067
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