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  2. Immunology/Inflammation
  3. CTLA-4
  4. Abatacept

Abatacept  (Synonyms: 阿巴西普; CTLA4lg; BMS-188667)

目錄號: HY-108829 純度: ≥99.0%
COA 技術(shù)支持

Abatacept (CTLA4lg) 是一種可溶性融合蛋白，由人 CTLA4 的胞外結(jié)構(gòu)域和人 IgG1 Fc 部分的片段 (鉸鏈，CH2 和 3 結(jié)構(gòu)域) 組成。Abatacept 是選擇性 T 細胞共刺激調(diào)節(jié)劑，也是一種用于自身免疫性疾病的蛋白活性分子。

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CAS No. : 332348-12-6

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥4000
In-stock
5 mg ￥8200
In-stock
10 mg   詢價  
50 mg   詢價  

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Other Forms of Abatacept:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains)[1]. Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases[1][2][3].

種屬

Human
體內(nèi)研究
(In Vivo)

與靜脈給藥組相比，Abatacept 減輕了爪水腫，皮下注射多劑量組的爪水腫明顯減少 (tobs=2.50)[2]。
Abatacept 在研究劑量范圍內(nèi)表現(xiàn)出線性 PK。NCA 清除率 (CL) 為 20.8 mL/day/kg，容積 (Vss) 為 146 mL/kg，皮下給藥的生物利用度 (F) 為 57.7%[2]。
Abatacept (口服；10 mg/kg；每 2 天一次) 降低活化 T 細胞 (CD44highCD62L–) 的比例并抑制純合子 DO11.10 RAG-2 中 ICOS 和 CD71 的上調(diào)–/– BALB/c (H-2d/d) 小鼠[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g[2]
Dosage: 10 mg/kg (IV), 20 mg/kg (SC single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29
Administration: IV or SC
Result: Reduced paw edema, and the SC Multiple-dose group showed significantly greater (tobs = 2.50) paw edema reduction compared with the IV dose group.
Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g[2]
Dosage: 10 mg/kg (IV), 20 mg/kg (SC single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29 (Pharmacokinetic Study)
Administration: IV or SC
Result: The NCA clearance (CL) is 20.8 mL/day/kg, volume (Vss) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7%.
Clinical Trial
CAS 號
性狀

液體

顏色

Colorless to light yellow

中文名稱

阿巴西普
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [CTLA4 (cytotoxic T-lymphocyte-associated protein 4, CD152)]2-IGHG1 Fc (Fragment constant)
Biological Activity
  • Flow cytometry analysis of CD80 overexpression CHOK1 cells labelling CD80 with Abatacept at 20nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Abatacept
目錄號：
HY-108829
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