| DC66546 |
R-Sirpiglenastat
|
R-Sirpiglenastat is the R- isomer of Sirpiglenastat(DRP-104).Sirpiglenastat (DRP104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response. |
| DC60597 |
AZD0780
|
AZD0780 is the first oral small molecule PCSK9 inhibitor for the treatment of hypercholesterolemia. |
| DC66114 |
FAPI-46
|
FAPI46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI 46 can be used for tumor imaging of a multitude of different cancers. |
| DC60580 |
Endosidin5(ES5)
|
Endosidine 5 (ES5), is one of the most potent small molecules interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm. The delivered mRNAs is greatly enhanced via inhibition of endocytic recycling in cells and in live mice. NAV2729 (NAV) and endosidin 5 (ES5), resulted in significant enhancement (1.5–2 folds) of LNP-mediated delivery of Fluc mRNAs. Incubation of NAV and ES5 together caused modest further increases in Fluc expression in comparison to the sole application of either compound. |
| DC90056 |
PLX-5622 HCl form (water solubility form)
|
PLX5622 is the HCl salt form of PLX-5622, which has better water solubility.PLX-5622 is a highly selective brain-penetrant CSF1R inhibitor (IC50=0.016 μM; Ki=5.9 nM) allowing for extended and specific microglial elimination, preceding and during pathology development. |
| DC60559 |
PT-179
|
PT-179 is a new orthogonal immunomodulatory drug (IMiD) derivative that binds CRBN but does not induce degradation of off-target proteins. PT-179 potently degrades proteins fused to SD40 at either the N or C terminus. |
| DC65841 |
MC1
|
MC1 is a selective and potent inhibitor for COX-2, and [11C]MC1 detected COX-2 in nonhuman primates after intracerebral injection of an inflammogen. |
| DC65839 |
MC1 Precursor
|
Precursor of MC1, which is a selective and potent inhibitor for COX-2, used as the radioligands for development as clinically useful PET radioligands. |
| DC65830 |
1-M-PES(1-Methoxy-5-methylphenazinium ethyl sulfate)
|
1-m-PES is an electron mediator which has higher stability of solutions than 1-Methoxy PMS. The stability in neutral to alkali conditions has been extremely improved with 1-Methoxy PES. 1-M-PES is a stable small-molecular compound and it has an equal or higher thermal stability than diaphorase. The 1-Methoxy PES solution can be stored long term. |
| DC65821 |
Upadacitinib hemihydrate
|
Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders. |
