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Dipivefrin (hydrochloride)

  Cat. No.:  DC11361  
Chemical Structure
64019-93-8
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More than 5000 active chemicals with high quality for research!
Field of application
Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.
Cas No.: 64019-93-8
Chemical Name: (1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene dipivalate hydrochloride
Synonyms: Dipivefrin hydrochloride
SMILES: O=C(C(C)(C)C)OC1=C(OC(C(C)(C)C)=O)C=C(C(CNC)O)C=C1.Cl
Formula: C19H30ClNO5
M.Wt: 387.9
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 μM).Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 μM.In cultured bovine corneal endothelial cells, dipivefrin (28 μM) enhances calcium signaling and induces cytotoxicity.Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 μM.5 Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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