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D,L-Buthionine-(S,R)-sulfoximine

  Cat. No.:  DC12252   Featured
Chemical Structure
5072-26-4
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More than 5000 active chemicals with high quality for research!
Field of application
D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
Cas No.: 5072-26-4
Chemical Name: Butanoic acid,2-amino-4-(S-butylsulfonimidoyl)-
Synonyms: Butanoic acid,2-amino-4-(S-butylsulfonimidoyl)-;DL-Buthionine-[S,R]-Sulfoximine;2-amino-4-(butylsulfonimidoyl)butanoic acid;D,L-Buthionine-(S,R)-sulfoximine;DL -BUTHIONINE-S,R-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine;DL-Buthionine-(S,R)-sulfoximine
SMILES: OC(C(N)CCS(CCCC)(=N)=O)=O
Formula: C8H18N2O3S
M.Wt: 222.30512
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: In Vitro Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. In Vivo Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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