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VU0155069

  Cat. No.:  DC21801   Featured
Chemical Structure
1130067-06-9
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More than 5000 active chemicals with high quality for research!
Field of application
VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM).
Cas No.: 1130067-06-9
Chemical Name: VU0155069
Synonyms: CAY10593;VU 0155069;(S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide;compound 69 [PMID: 19136975];VU0155069;N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide;N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide;GTPL8782;BDBM50258182
SMILES: ClC1C=CC2=C(C=1)NC(N2C1CCN(C[C@H](C)NC(C2C=CC3C=CC=CC=3C=2)=O)CC1)=O
Formula: C26H27ClN4O2
M.Wt: 462.971184968948
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM); sensitizes MCF7 and MDA-MB-231 breast cancer cells to doxorubicin-induced cytotoxicity, suppresses growth of colorectal cancer activated by the Wnt/β-catenin and PI3K signaling pathways.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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