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  2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. CFL-120

CFL-120  (Synonyms: 4,6-二氯-1H-吲哚-2,3-二酮)

目錄號(hào): HY-W041315
COA 產(chǎn)品使用指南

CFL-120 是一種有效的 KRasG12C 抑制劑。CFL-120 具有抗增殖作用。CFL-120 顯示出抗癌活性。CFL-120具有肺癌研究的潛力。

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CFL-120 Chemical Structure

CFL-120 Chemical Structure

CAS No. : 18711-15-4

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1 g ￥300
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5 g ￥500
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查看 Ras 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].

IC50 & Target[1]

KRAS(G12C)

 

體外研究
(In Vitro)

CFL-120 (72 h) 顯示出抗增殖作用，對(duì) H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 細(xì)胞的 IC50 值分別為 111.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

CFL-120 (5 mg/kg，5 次治療；15 mg/kg，5 次治療；30 mg/kg，3 次治療；i.p.) 減少皮下人肺癌 H1792 (KRasG12C 突變體) 和 LCLC-103H (KRasWT) 小鼠腫瘤模型的生長(zhǎng)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1]
Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments
Administration: I.p.
Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%.
分子量

216.02

Formula

C8H3Cl2NO2
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

中文名稱

4,6-二氯-1H-吲哚-2,3-二酮
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
CFL-120
目錄號(hào)：
HY-W041315
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