Azamulin is an irreversible, highly selective inhibitior of human CYP3Aa. Azamulin has CYP3A inhibition activity with IC₅₀ values range from 0.03-0.24 μM. Azamulin can be used for the research of metabolism and antiinfection^[1].

Azamulin 具有 CYP3A 抑制活性，IC₅₀ 值范圍為 0.03-0.24 μM^[1]。
Azamulin 對(duì) CYP3A 的抑制呈 S 型曲線，并且對(duì)底物 7-benzyloxy-4-trifluoromethylcoumarin, testosterone 和 midazolam 表現(xiàn)良好^[1]。
Azamulin (4.8 μM; 10 min) 在 NADPH 存在的情況下抑制約 95% 的睪酮 6β-羥化酶活性^[1]。
Azamulin 在乙腈中儲(chǔ)存長達(dá) 12 天時(shí)表現(xiàn)出良好的化學(xué)穩(wěn)定性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

478.65

C₂₄H₃₈N₄O₄S

76530-44-4

Room temperature in continental US; may vary elsewhere.

• [1]. David M Stresser, et al. Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. Drug Metab Dispos. 2004 Jan;32(1):105-12.  [Content Brief]