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  2. Anti-infection
  3. RSV
  4. Palivizumab

Palivizumab  (Synonyms: 帕利珠單抗; MEDI 493)

目錄號(hào): HY-P9944 純度: 99.43%
COA

Palivizumab (MEDI 493) 是一種人源化呼吸道合胞病毒 (RSV) 單克隆抗體。Palivizumab 可以結(jié)合 RSV F 蛋白， Kd 值為 1.4 nM。Palivizumab 可以預(yù)防棉鼠的呼吸道合胞病毒感染。

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CAS No. : 188039-54-5

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1 mg ￥5200
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice[1].
同型

Human IgG1 kappa
推薦同型對(duì)照抗體
種屬

Humanized
體外研究
(In Vitro)

Palivizumab 具有 RSV 中和活性，與 IgG1 蛋白的 EC50 值為 0.95850 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Palivizumab (0.625-5 mg/kg (肌肉注射) 或 0.312-10 mg/kg (靜脈注射); 單劑量) 可以預(yù)防棉鼠的呼吸道合胞病毒感染[1]。
Palivizumab (0.05 mg/kg; 單劑量; 鼻內(nèi)給藥) 可以在小鼠中預(yù)防 RSV 感染[2]。
Palivizumab (15 mg/kg; 單劑量; 皮下注射) 可以抑制 RSV 誘導(dǎo)的大鼠氣道神經(jīng)源性炎癥[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The cotton rat model of RSV infection[1].
Dosage: 0.625-5 mg/kg (i.m.) or 0.312-10 mg/kg (i.v.)
Administration: Intramuscular injection (i.m.) or intravenous injection (i.v.); single dose
Result: Reduced virus replication and did not cause RSV infection or pathological increase in both initial and secondary attacks.
Animal Model: BALB/c mice[2].
Dosage: 0.05 mg/kg
Administration: Intranasally administered; single dose
Result: Reduced the RSV load.
Animal Model: Capsaicin-induced neurogenic inflammation in the airways of rats[3].
Dosage: 15 mg/kg
Administration: Subcutaneous injection (s.c.); single dose
Result: Reduced neurogenic extravasation and neurogenic inflammation.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

帕利珠單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料

純度: 99.43%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Palivizumab
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HY-P9944
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