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  1. Immunology/Inflammation
  2. CD73
  3. Oleclumab

Oleclumab  (Synonyms: 奧來(lái)魯單抗; MEDI9447)

目錄號(hào): HY-P99039 純度: 99.90%
COA

Oleclumab (MEDI9447) 是一種靶向 CD73 的人源 IgG1λ 單克隆抗體,可抑制胞外酶 CD73 核酸外切酶活性。Oleclumab 可調(diào)整腫瘤微環(huán)境中骨髓和淋巴浸潤(rùn)白細(xì)胞群組成,具有抗腫瘤活性。

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CAS No. : 1803176-05-7

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1 mg ¥4500
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity[1][2].

同型

Human IgG1 lambda1

推薦同型對(duì)照抗體
種屬

Human

體內(nèi)研究
(In Vivo)

Oleclumab (10 mg/kg; ip; 每 3 天一次,共 4 次) 在小鼠 Balb/c 同基因 CT26 結(jié)腸癌腫瘤模型中,增加活化 CD8S+ 淋巴細(xì)胞群的比例,并顯著抑制腫瘤生長(zhǎng)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine, Balb/c, syngeneic CT26 colon carcinoma tumor model[2]
Dosage: 10 mg/kg
Administration: ip; 2 time per week, for 2 weeks
Result: Inhibited tumor growth by 50% or greater from study day 7 to study day 16 when compared with isotype control antibody-treated groups.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

奧來(lái)魯單抗;奧來(lái)珠單抗

運(yùn)輸條件

Shipping with dry ice.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 lambda2
純度 & 產(chǎn)品資料

純度: 99.90%

參考文獻(xiàn)
  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Oleclumab
目錄號(hào):
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