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  2. 天然產(chǎn)物
  3. 疾病研究領域 植物 糖類 其他類
  4. 薔薇科 感染 炎癥/免疫 多糖
  5. 蘋果
  6. Polygalacturonic acid

Polygalacturonic acid  (Synonyms: Galacturonic acid polymer)

目錄號: HY-N6613 含量: 95.16%
COA 產(chǎn)品使用指南

Polygalacturonic acid (Galacturonic acid polymer) 是透明膠狀酸，是細胞壁的主要成分。Polygalacturonic acid 可用于制備銀納米顆粒 (AgNPs)，作為抗氧化劑和抗炎劑，保護細胞免受 ROS 升高的破壞作用，并加速傷口愈合。Polygalacturonic acid 納米顆粒也表現(xiàn)出抗菌活性。

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Polygalacturonic acid Chemical Structure

Polygalacturonic acid Chemical Structure

CAS No. : 25990-10-7

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].

體外研究
(In Vitro)

Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Full thickness wound model in albino rats (60-day-old, 180 g)[2]
Dosage: Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration: Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result: Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively.
Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.
Formula

(C6H10O7)x
CAS 號
性狀

固體

顏色

Off-white to light yellow

中文名稱

聚半乳糖醛酸； 半乳糖醛酸聚合物
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 95.16%

參考文獻
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Polygalacturonic acid
目錄號：
HY-N6613
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