5 | 1227162-34-6 | CC-5013-d5 | 來那度胺-d5 | 雷那度胺-d5 | Isotope-Labeled Compounds | Ligands for E3 Ligase | Molecular Glues | Apoptosis | E3 ligase-recruiting Moiety | Inhibitor | inhibitor | inhibit"/>

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  1. Others PROTAC Apoptosis
  2. Isotope-Labeled Compounds Ligands for E3 Ligase Molecular Glues Apoptosis
  3. Lenalidomide-d5

Lenalidomide-d5  (Synonyms: 來那度胺-d5; CC-5013-d5)

目錄號: HY-A0003S 純度: 99.32%
COA 產(chǎn)品使用指南

Lenalidomide-d5 是 Lenalidomide 氘代物。Lenalidomide (CC-5013) 是 Thalidomide 的衍生物,也是一種具有口服活性免疫調(diào)節(jié)劑,以分子膠的方式作用。Lenalidomide (CC-5013) 是一種泛素 E3 連接酶 cereblon (CRBN) 的配體,可通過 CRBN-CRL4 泛素連接酶對兩種淋巴轉(zhuǎn)錄因子 IKZF1IKZF3 進(jìn)行選擇性泛素化和降解。Lenalidomide (CC-5013) 特別地抑制成熟 B 細(xì)胞淋巴瘤 (包括多發(fā)性骨髓瘤) 的生長,并誘導(dǎo) T 細(xì)胞釋放白細(xì)胞介素-2 (IL-2)

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Lenalidomide-d<sub>5</sub> Chemical Structure

Lenalidomide-d5 Chemical Structure

CAS No. : 1227162-34-6

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Other Forms of Lenalidomide-d5:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Lenalidomide-d5 is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].

體外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

264.29

Formula

C13H8D5N3O3

CAS 號
非標(biāo)記 CAS
性狀

固體

顏色

White to off-white

中文名稱

來那度胺-d5;雷那度胺-d5

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Lenalidomide-d5
目錄號:
HY-A0003S
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