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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Methyl 1-Boc-azetidine-3-carboxylate

Methyl 1-Boc-azetidine-3-carboxylate 

目錄號: HY-40151 純度: ≥97.0%
COA 產(chǎn)品使用指南

Methyl 1-Boc-azetidine-3-carboxylate 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗體偶聯(lián)活性分子 (ADCs)。Methyl 1-Boc-azetidine-3-carboxylate 也是一個基于烷基鏈 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

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Methyl 1-Boc-azetidine-3-carboxylate Chemical Structure

Methyl 1-Boc-azetidine-3-carboxylate Chemical Structure

CAS No. : 610791-05-4

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5 g ￥100
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25 g ￥360
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100 g ￥1250
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500 g ￥5962
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

IC50 & Target

Non-cleavable Linker

 

體外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

215.25

Formula

C10H17NO4
CAS 號
性狀

液體（密度：1.152±0.06 g/cm3）

顏色

Colorless to light yellow

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: 98.72%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Methyl 1-Boc-azetidine-3-carboxylate
目錄號：
HY-40151
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