Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator^{[1][2][3][4][5][6]}.

Quercetin GMP (10，50 和 100 μM) 促進(jìn)間充質(zhì)干細(xì)胞 (mASCs) 成骨^[1]。
Quercetin GMP (0.1-10 μM) 劑量依賴性地降低 RANKL 誘導(dǎo)的破骨細(xì)胞生成^[2]。
Quercetin GMP (2 μM) 劑量依賴性地增強大鼠骨髓間充質(zhì)干細(xì)胞 (rBMSCs) 的成骨分化和血管生成因子分泌^[3]。
Quercetin GMP (2-5 μM) 通過抑制破骨細(xì)胞的分化和激活來抑制骨吸收^[4]。
Quercetin GMP (5 μM; 2-4 d) 劑量依賴性地增加成骨分化^[5]。
Quercetin GMP (5 μM; 2-4 d) 增加成骨細(xì)胞分化和細(xì)胞外基質(zhì)生成和礦化^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

302.24

C₁₅H₁₀O₇

117-39-5

固體

Light yellow to yellow

Room temperature in continental US; may vary elsewhere.

• [1]. Zhou C, Lin Y. Osteogenic differentiation of adipose-derived stem cells promoted by quercetin. Cell Prolif. 2014 Apr;47(2):124-32.  [Content Brief]

  [2]. Wattel A, et al. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1. J Cell Biochem. 2004 May 15;92(2):285-95.  [Content Brief]

  [3]. Zhou Y, et al. The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One. 2015 Jun 8;10(6):e0129605.  [Content Brief]

  [4]. Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9.  [Content Brief]

  [5]. Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78.  [Content Brief]

  [6]. Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021.  [Content Brief]