Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases^{[1][2][3][4][5]}.

Staurosporine (GMP) (316?nM; 24?h) 誘導(dǎo) RGC-5 細(xì)胞產(chǎn)生強(qiáng)健的神經(jīng)突^[1]。
Staurosporine (GMP) (25 和 100 nM; 12 h) 誘導(dǎo) SH-SY5Y 細(xì)胞分化，神經(jīng)突突起增加并伴有顯著的分支，減少細(xì)胞體尺寸^[2]。
Staurosporine (GMP) (20 nM) 誘導(dǎo)人成神經(jīng)細(xì)胞瘤細(xì)胞系細(xì)胞分化^[3]。
Staurosporine (GMP) (5 nM) 可增強(qiáng)由 1 alpha,25 dihydroxyvitamin D3，dbc AMP，全反式-維甲酸 (RA)，放線菌素 D (Act D) 和其他化合物誘導(dǎo)的 HL-60-cell 細(xì)胞分化^[4]。
Staurosporine (GMP) (1 μM; 15 d) 誘導(dǎo)人成神經(jīng)細(xì)胞瘤細(xì)胞分化^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

466.53

C₂₈H₂₆N₄O₃

62996-74-1

固體

Off-white to light yellow

Room temperature in continental US; may vary elsewhere.

• [1]. Ganapathy PS, et al. Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. Curr Eye Res. 2010 Jan;35(1):80-90.  [Content Brief]

  [2]. Pregi N, et al. Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells. Biochim Biophys Acta. 2006 Feb;1763(2):238-46.  [Content Brief]

  [3]. Hajimu MORIOKA, et al. Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1. Agricultural and Biological Chemistry. 1985; 1959-1963.

  [4]. Okazaki T, et al. Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds. Exp Hematol. 1988 Jan;16(1):42-8.  [Content Brief]

  [5]. Yuste VJ, et al. The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells. J Neurochem. 2002 Jan;80(1):126-39.  [Content Brief]