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  2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Resiquimod

Resiquimod  (Synonyms: R848; S28463)

目錄號: HY-13740G
產(chǎn)品使用指南

Resiquimod (R848) (GMP) 是 GMP 級別的 Resiquimod (HY-13740)。GMP 級別的小分子可用做細胞療法中的輔助試劑。Resiquimod 是一種 Toll 樣受體 7 和 8 (TLR7/TLR8) 激動劑。Resiquimod (GMP) 可誘導人 mMDSC 分化成熟為炎性巨噬細胞。

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Resiquimod Chemical Structure

Resiquimod Chemical Structure

CAS No. : 144875-48-9

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10 mg ￥11880
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50 mg ￥37800
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Other Forms of Resiquimod:

查看 Toll-like Receptor (TLR) 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages[1][2][3].

IC50 & Target[1]

TLR7

 

TLR8

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.75 μM
Compound: R848
Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
[PMID: 32001135]
HEK293 EC50
1.4 μM
Compound: 2
Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
[PMID: 22837811]
HEK293 EC50
1.5 μM
Compound: 2
Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
[PMID: 24383475]
HEK293 EC50
260.1 nM
Compound: 2
Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
[PMID: 20232824]
HEK293 EC50
4 μM
Compound: Resiquimod
Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay
Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay
[PMID: 27270029]
HEK293 EC50
4.5 μM
Compound: 2
Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
[PMID: 24383475]
HEK293 EC50
5.87 μM
Compound: R848
Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay
[PMID: 32001135]
HEK293 EC50
6.4 μM
Compound: 2
Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
[PMID: 22837811]
PBMC EC50
24 nM
Compound: R848
Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay
Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay
[PMID: 17548497]
PBMC EC50
26.5 nM
Compound: R848
Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay
Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay
[PMID: 17548497]
體外研究
(In Vitro)

Resiquimod (GMP) (3 μg/mL，5 天) 誘導人 mMDSC 成熟為炎性巨噬細胞 (MACinflam)[1]。
Resiquimod (GMP) (3 μg/mL，3 天) 在人 mMDSC 中產(chǎn)生 IL-6 和 IL-12[1]。
Resiquimod (GMP) (2.5 μg/mL，7 天) 將記憶 B 細胞轉(zhuǎn)分化為產(chǎn)生 IgG 的漿細胞[2]。
Resiquimod (GMP) (5 μg/mL，5 天) 誘導 MDSCs 分化為成熟的骨髓細胞[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

314.38

Formula

C17H22N4O2
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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