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  2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Aminopeptidase mGluR
  4. β-Spaglumic acid

β-Spaglumic acid  (Synonyms: β-NAAG; β-N-Acetylaspartylglutamic acid)

目錄號(hào): HY-130553
產(chǎn)品使用指南 技術(shù)支持

β-Spaglumic acid (β-NAAG) 是一種競(jìng)爭(zhēng)性的 NAAG 肽酶抑制劑 (Ki=1 μM)，可以保護(hù)脊髓神經(jīng)元免受興奮性毒性和缺氧性損傷。β-Spaglumic acid 也是一種選擇性的 mGluR3 拮抗劑 (mGluR3 受體的功能是調(diào)節(jié)海馬中依賴激活的突觸電位)。β-Spaglumic acid 可用于神經(jīng)保護(hù)相關(guān)的研究。

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β-Spaglumic acid Chemical Structure

β-Spaglumic acid Chemical Structure

CAS No. : 4910-46-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥201
1 - 2 周
10 mg ￥326
1 - 2 周
50 mg   詢價(jià)  
100 mg   詢價(jià)  

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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 Aminopeptidase 亞型特異性產(chǎn)品:

查看 mGluR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 μM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies[1][2].

IC50 & Target

NAAG peptidase, mGluR3[1][2].
體外研究
(In Vitro)

β-Spaglumic acid (63-1000 μM; 2 h) protects against NMDA-induced injury of spinal cord cells in a dose-dependent manner[1].
β-Spaglumic acid (0-1000 μM; 2 h) protects spinal cord cells against hypoxia[1].
β-Spaglumic acid (500 μM) significantly reduces intraneuronal free Ca2+ responses upon neuronal exposure to 25 μM NMDA[1].
β-Spaglumic acid (100 μM; 7 min) antagonizes mGluR3 in cerebellar granule cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Spinal cord cells (NMDA-induced) (from spinal cords removed from prenatal day 15 Sprague-Dawley rat fetuses)
Concentration: 63-1000 μM
Incubation Time: 2 h
Result: Led to a significant attenuation of NMDA toxicity at a concentration of 63 μM and completely blocked NMDA toxicity with 500 and 1000 μM concentrations.
Apparently minimized the basal loss of cell viability associated with experimental handling of the cells (e.g. serum removal, media changes).

Cell Viability Assay[1]

Cell Line: Spinal cord cells (hypoxic-induced)
Concentration: 0-1000 μM
Incubation Time: 2 h
Result: Provided 75% protection during hypoxia when at 8 μM and completely eliminated hypoxia-induced loss of viability (107.4-114.4% protection, respectively) when at 63-1000 μM.

Cell Viability Assay[2]

Cell Line: Cerebellar granule cells (expressing group I-III mGluRs)
Concentration: 100 μM
Incubation Time: 7 min
Result: Blocked NAAG inhibition of forskolin-stimulated cAMP formation via mGluR3.
分子量

304.25

Formula

C11H16N2O8
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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產(chǎn)品名稱：
β-Spaglumic acid
目錄號(hào)：
HY-130553
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