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  2. Anti-infection Apoptosis
  3. Antibiotic Fungal Apoptosis
  4. Reveromycin A

Reveromycin A  (Synonyms: 雷弗霉素A)

目錄號: HY-129337 純度: 99.00%
COA 產(chǎn)品使用指南 技術(shù)支持

Reveromycin A 是一種從鏈霉菌屬中分離出來的苯甲醌類抗生素 (antibiotic)，是選擇性的真核細胞中蛋白質(zhì)合成 (protein synthesis) 抑制劑。Reveromycin A 通過誘導(dǎo)破骨細胞的凋亡 (apoptosis) 來抑制骨吸收。Reveromycin A 對腫瘤細胞系具有抗增殖活性，并具有抗真菌 (antifungal) 活性。

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Reveromycin A Chemical Structure

Reveromycin A Chemical Structure

CAS No. : 134615-37-5

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥18200
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2].

體外研究
(In Vitro)

Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase[2].
Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

660.79

Formula

C36H52O11
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

雷弗霉素A
結(jié)構(gòu)分類
初始來源

Actinomycete
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Reveromycin A
目錄號：
HY-129337
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