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  2. Immunology/Inflammation
  3. Interleukin Related
  4. Canakinumab

Canakinumab  (Synonyms: 卡那奴單抗; Ilaris; ACZ 885)

目錄號(hào): HY-108810 純度: 99.64%
COA

Canakinumab (ACZ885) 是一種重組的人抗 IL-1β 單克隆抗體。Canakinumab 顯示出對(duì)人類和絨猴 IL-1β 的 IC50 值為分別為 43.6 和 40.8 pM。Canakinumab 的作用模式是基于對(duì) IL-1β 信號(hào)的中和，從而抑制與自身免疫性疾病相關(guān)的炎癥。

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CAS No. : 914613-48-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥4000
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].

同型

Human IgG1(K214R) kappa
推薦同型對(duì)照抗體
種屬

Human
IC50 & Target

IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2]
體外研究
(In Vitro)

Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2]. Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

卡那奴單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
純度 & 產(chǎn)品資料

純度: 99.64%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Canakinumab
目錄號(hào)：
HY-108810
需求量：