L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively^[1].

L-AP3 inhibits D-phosphoserine and L-phosphoserine with K_is of 151 μM and 845 μM, respectively^[1].
L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus^[1].
L-AP3 may have selectivity for Group II subtypes since it inhibits [³H]glutamate binding to mGlu3, receptors (K_i 125 μM)^[1].
L-AP3 is a potent inhibitor of sodium-dependent L-[³H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

169.07

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23052-80-4

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• [1]. J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25.  [Content Brief]