Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a K_d of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

Kd: 5.44 nM (Rat uterine progesterone receptor)^[1]

Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a K_d of 5.44 nM for rat uterine progesterone receptor^[1]. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

328.45

C₂₁H₂₈O₃

58691-88-6

諾美孕酮；諾美孕酮

Room temperature in continental US; may vary elsewhere.

• [1]. Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56(6):325-8.  [Content Brief]

  [2]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.  [Content Brief]